Scientist, In Vivo Cancer Modeling
Cloverleaf Bio · Boston, MA
Work closely with the founding team to develop a novel family of engineered RNA therapeutics. Design and run in-house mouse studies, coordinate CRO studies, and run in vitro experiments to characterize candidate RNAs.
What you'll do
- Design and execute in-house animal experiments in mice
- Plan and coordinate toxicity, pharmacology and efficacy studies at CROs
- Perform in vitro experiments to characterize mechanism and potency of candidate RNAs
- Provide in vivo pharmacology and physiology expertise for tRNA therapeutics
Requirements
- PhD in Cancer Biology, Molecular Biology, or related fields
- Hands-on experience with mouse models of disease (preferably oncology), tissue collection and processing, and drug administration including IV and subcutaneous injections
- Ability to independently plan and execute in vivo studies, data analysis and interpretation
- Skilled in mammalian cell culture and molecular biology techniques
Nice to have
- Strong molecular/cell biology experience, particularly in immunology, RNA biochemistry and/or protein biochemistry
- Hands-on experience with flow cytometry, IHC, ELISA
- Experience designing/developing RNA therapeutics and lipid nanoparticles
- Previous experience selecting and overseeing work at CROs
Benefits
- Competitive salary commensurate with experience
- Strong equity incentives
- Medical, dental, and vision coverage
- 401(k) with employer match
Skills
Outlined skills are listed as required.
Full original description
About Us
Cloverleaf Bio is an early-stage therapeutics company that is developing a new class of engineered RNA therapeutics.
The Job
We are seeking an experienced in vivo Scientist to join our team. In this position, you will work in close conjunction with our founding team in the creation and development of a completely novel family of RNA therapeutics.
Your responsibilities will include designing and executing in house animal experiments in mice, proposing, planning and coordinating toxicity, pharmacology and efficacy studies at CROs, performing in vitro experiments to characterize the mechanism and potency of candidate RNAs, and providing in vivo pharmacology and physiology expertise to accelerate development of our tRNA therapeutics.
When & Where
Location: Boston, MA
Work Model: Full-time onsite
About You
Excited by the science. We are excited by how science can improve the world and are looking for people who are too.
Flexible. We wear many different hats and are looking for people who are willing to do whatever it takes to pitch in and get the job done.
Resilient. Working in an early-stage startup can be hard. Science is hard. We are looking for people who have a demonstrated track record of sticking with complex problems for the long haul.
Cooperative. As a small team, communication and collaboration are key. We are looking for people who thrive working both independently and collaboratively.
Qualifications:
- PhD in Cancer Biology, Molecular Biology, or related fields.
- Must have hands-on experience with mouse models of disease (preferably oncology), tissue collection and processing, and routine drug administration including intravenous and subcutaneous injections.
- Demonstrated ability to independently plan and execute in-vivo studies, data analysis and interpretation.
- Skilled in mammalian cell culture and molecular biology techniques.
Nice to haves:
- Strong molecular/cell biology experience, particularly in immunology, RNA biochemistry and/or protein biochemistry.
- Hands-on experience with flow cytometry, IHC, ELISA.
- Experience with design/development RNA therapeutics and lipid nanoparticles.
- Previous experience selecting and overseeing work at CROs.
Benefits:
- Competitive salary commensurate with experience and strong equity incentives.
- Medical, dental, and vision coverage.
- 401k retirement including employer match.
- A stimulating, collegial, and fast-paced environment.